Unlocking the Secrets of Gene Therapy for Bodybuilding
Peptide Doctor Shares Fat Loss & Muscle Gain Secrets with Gene Therapy
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Summary
In an engaging conversation between Thomas DeLauer and Dr. KH, they explore the frontier of gene therapy and peptides in achieving optimal body composition—specifically in fat loss and muscle gain. Dr. KH introduces the concept of peptide gene therapy using plasmids to continually express beneficial genes like folistatin, thereby reducing myostatin and boosting muscle mass. The discussion also extends to innovative ways of managing inflammation via microbiome health and vagus nerve therapies, emphasizing their potential in enhancing overall health and training outcomes. This video delves deeply into the biotechnological advancements and their practical applications in fitness and health.
Highlights
Introducing folistatin gene therapy for extended muscle growth and reduced inflammation. 💉
Exploring the benefits of plasmid-based gene therapy that lasts up to two years. 🔬
Understanding the link between gut health and chronic conditions like back pain. 🚑
The significance of systemic approaches in managing inflammation and improving metabolism. 🔄
Exciting developments in microbiome health, including fecal microbial transplants for athletes. 🏃♂️
Key Takeaways
Gene therapy with plasmids can aid in muscle growth by modulating myostatin levels. 💪
Folistatin gene therapy has shown promise in reducing systemic inflammation. 🔥
Emerging therapies focus on the gut-brain axis to optimize health. 🧠
Practices like vagus nerve stimulation play a crucial role in stress management and recovery. 🧘♂️
There’s a growing emphasis on understanding the microbiome's role in overall health. 🦠
Overview
Imagine taking your fitness to the next level by altering your genes! Dr. KH offers insights into gene therapy using folistatin, a peptide that suppresses myostatin to help build muscles. This is a game-changer, especially since traditional methods can be quite cumbersome and short-lived. With modern plasmid technology, the therapy promises sustained muscle growth for years!
Gut health isn't just about digestion—it's a foundation of overall well-being. In this discussion, we delve into how the gut's condition can affect everything from inflammation to even chronic back pain! Dr. KH opens up about innovative treatments like targeted fecal microbial transplants that aim to alter microbiomes for better health outcomes. It's a gut-turning revelation that shows just how interconnected our body systems are.
Managing stress and recovery through the vagus nerve lights up the holistic approach to health. Through therapies that stimulate this crucial nerve, Dr. KH illustrates a path to achieving balance between the mind and body. In the world of high stakes fitness, understanding and implementing such biotechnological advances could radically enhance one's training blueprint. Keep calm and biohack on!
Chapters
00:00 - 03:00: Introduction to Peptide and Gene Therapy The chapter introduces the concept of peptide and gene therapy as innovative approaches to optimize body composition. Dr. KH discusses the shift in scientific and medical communities towards utilizing these methods, beyond traditional diet and exercise, for muscle building and fat loss. The focus is on how peptides and gene exploration are starting to play a role in achieving these physical health goals. The audience is expected to have a basic understanding of peptides as the discussion deepens into advanced therapeutic techniques.
03:00 - 07:00: Plasmid and Minicircle Technology This chapter explores plasmid and minicircle technology in the context of peptides, particularly focusing on insulin and other bioidentical peptide hormones like fallatin. It explains that peptides, typically chains of amino acids, have become well-understood over the years. Insulin, being a well-known peptide developed 100 years ago, serves as a familiar example. The chapter also covers fallatin, a peptide that has been studied for over two decades, and highlights its function as a myostatin inhibitor in the body.
07:00 - 15:00: Inflammation and Gut Health This chapter discusses the role of myostatin and its counterpart, fostatin, in muscle growth and bodybuilding. Myostatin is a gene that limits muscle growth, famously illustrated by the Belgian Blue cows, which have a myostatin knockout gene allowing them to grow significantly more muscle. In humans, higher levels of fostatin can lead to decreased myostatin levels, potentially increasing muscle mass. This concept attracted bodybuilders, particularly in the 1980s and 1990s, who experimented with fostatin through regular injections. However, it's noted that fostatin has a very short half-life.
15:00 - 19:00: Vagus Nerve and Stress Resilience The chapter discusses an innovative approach to stress resilience through plasma gene therapy focusing on the Vagus nerve. The gene therapy involves a one-time injection that causes cells to express a specific gene over a period of one to two years, potentially replacing the need for frequent injections used by some, like bodybuilders, to combat stress. This method presents a more practical and long-term solution for stress management.
19:00 - 23:00: Gut Health, Transplants, and FMT This chapter delves into the concept of plasmids, which are molecules derived from bacteria used to transfer information. The application discussed involves isolating plasmids to use for medical purposes, specifically targeting gut health and fecal microbiota transplants (FMT). The transcript emphasizes that plasmids are not actual bacteria; instead, they are inert agents that do not stimulate the immune system or migrate within the body, making them safe for use. Plasmids have been studied for over two decades, establishing their safety and efficacy in medical interventions.
23:00 - 27:00: Gut Microbiome in Sports and Probiotics The chapter begins with a discussion about the gut microbiome's role in sports and probiotics, highlighting emerging research in this field.
27:00 - 28:30: Conclusion and Contact Information The chapter discusses the breakthrough technology developed by Minicircle, a company that specializes in gene therapy. They have engineered plasmids that can remain active in the human body for extended periods, from at least one year and potentially up to two years, providing prolonged gene expression. This represents a significant advancement in genetic therapies. Additionally, a promotional offer is mentioned: a 10% discount on Timeline Nutrition products.
Peptide Doctor Shares Fat Loss & Muscle Gain Secrets with Gene Therapy Transcription
00:00 - 00:30 all right Dr KH there's a lot of people that are looking at sort of different ways to achieve optimal body composition you know obviously we talk on this channel all the time about diet exercise whatever but when you're starting to look at building muscle potentially losing more fat what are some of the things that we're starting to see in the scientific community and even the medical community that are a little different maybe looking at genes and whatnot yeah so really what we're using is we're using a peptide gene therapy so most most of your audience is probably familiar with peptides just because
00:30 - 01:00 become pretty popular and OIC for example is the most popular peptide but insulin is also a peptide that was made 100 years ago so people kind of have idea okay I get what a peptide is you know it's it's basically a you know chain of amino acids usually to by definition is technically by like 54 you know so it's a short sequence of amino acids and and there's one called fallatin that's been around for you know over two decades in terms of being studied but it's a bioidentical peptide hormone in your body and what it does is it inhibits myostatin and people
01:00 - 01:30 probably have heard of myostatin because of those big Belgian Blue cows that have a myostatin knockout Gene and so they can put on as much muscle as possible so if you think about it at a very fundamental level if you have higher fost Statin then you're going to have lower myostatin which potentially could increase your muscle mass and that's why bodybuilders used to play around with f Statin probably dating back to the 80s or 90s because it was around and they used to just inject themselves like every day H like and as bodybuilders do and but it turns out that fall has a very short halflife it only lasts for a
01:30 - 02:00 couple hours so it's not practical to inject yourself like 10 times a day I'm sure there are some bodybuilders who did that but to do that every day for you know years doesn't make sense uh so we have to figure out a different mechanism to do that and that's where this plasma gene therapy comes in so what does that what does that look like is it just basically uh it's incorporating it into your body over a longer period of time like how does that work so it's getting your cell to express the fost Statin Gene for one to two years with one injection and how does it do that it
02:00 - 02:30 we're using what's called a plasmid a plasmid is derived from bacteria it's a way to exchange information so think of it like giving your business card to someone when bacteria need to tell someone else a message they they use this plasmid and so we're isolating that plasmid so we're not actually injecting bacteria into your body we're just injecting this plasmid which plasmids have been around again for 20 years they're well studied they're inert meaning they don't migrate anywhere they don't cause immunogenicity meaning they don't stimulate your immune system just
02:30 - 03:00 kind of just sit there and tell your cell hey produce more of this Gene so you're so people are probably wondering okay if Plasma's been around forever how come this doesn't come out earlier it's because plasmids get silenced there's something called trans gene silencing meaning when you put a plasmid into your body your your cell will shut it off and it can do that relatively quickly meaning most plasma will only stay in your body for a couple days so it doesn't really solve that problem so again if you use a plasmid normally and you inject yourself with this whatever Gene you want it's going to be shut off in a few days and it's not practical so inject yourself every couple days with a
03:00 - 03:30 plasmid so here comes minicircle which is a company I work with they figured out how to make these plasmids stay in your body longer so they won't be shut off they'll within a few days in fact they'll be they stay on for at least minimum like a year with the right dosing uh but can stay up to like two years so it's pretty incredible in terms of just a breakthrough technology of getting these plasmas to express the gene of Interest after today's video I put a link down below for 10% off of your lithan a from timeline Nutrition
03:30 - 04:00 urethan a is what is called a postbiotic it's something that is extracted typically in this case from pomegranates and it's a compound that induces what is called mitophagy so it encourages the mitochondria to essentially go through a recycling now mitop pure which is the patented version of urethan a has a lot of clinical studies published on it very legit stuff I've talked about it with Dr Gabriel lion if you're looking at trying
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04:30 - 05:00 the very least at least check out the link and read a little bit more about it because it's not just Thomas Delow talking this is very real stuff so link is below this video in the top line of the description so mechanistically like why does our body have this thing this myostat and that prevents us from building muscle like it seems like kind of just like a giant uh in a way why is this like I want to get more jacked why is this thing stopping me yeah it's essentially just a way for your body to have a feedback loop or a regulatory mechanism to prevent too much muscle
05:00 - 05:30 growth because if you have uncontrolled muscle growth it can put too much stress on your tendons and it can put too much stress potentially on your bones uh but the other thing too is you know like in those uh Belgian Blue cows for example uh they they get so much muscle growth that it may increase your risk of cancer too uh because you just have this anabolic signal all the time interesting yeah that makes sense so I mean it's almost like I didn't realize that the bells and blue cows kind of run that risk so do they do they in essence by having this knockout do they ever just
05:30 - 06:00 like Snap tendons or do they have since they're such a unique Brea that's not just like a mil set I know you're not a cow expert but like how are they not snapping tendons left and right does myo Staton have an impact on that too so you can actually like maybe tendon tinile strength grows as or yeah I mean that's one of the biggest actually that's a common concern people ask with our F Statin because they're like what if I put on too much muscle and my tendons can't keep up uh am I going to injure my tendons or bones uh I mean because of the way we're doing it's not like we're knocking out the gene so it's a
06:00 - 06:30 antagonistic relationship right so the higher your fost Statin the lower your myostatin so it's not like we're knocking it out like those cows but because those cows have a complete knockout but you know I I don't know why they don't break their bones or they're not pushing their bodies I was going to say exactly it's probably not it's probably because of that but it's it's funny you mention that because I treated there's um there's Deon larett who's a professional arm wrestler he's actually the number one armed wrestler in the world and he was where because there's some mechanistic data suggesting that in in rat when you give them fall Statin
06:30 - 07:00 that might make their chance of having bone injuries because again the same principle right you're putting too much stress on the on the bones uh but you know we so he was kind of hesitant to do the procedure or to do the injection uh but but he did it and it worked out great he actually won the championship and he said the reason he did was because of the fal Sten he said he had more energy more strength he was stronger than he ever was and he's pushing 50 uh and he he talked about this publicly so it's out there so um do people ever what about from like a fat loss perspective it doesn't necessarily
07:00 - 07:30 have to be you know fost Statin gene therapy like what are people doing maybe from U you know an obesity side of things like I mean is full Statin have an application there or I mean indirectly I suppose it would obviously higher RMR if you're putting on more muscle mass but yeah it's not it's not just muscle though uh fallatin significantly reduces systemic inflammation uh and that's what one of the things that we measured and saw in the clinical trial and I've see consistently with patients with biomarkers so coming back to reducing inflammation that can help with cellular metabolism because you have less of
07:30 - 08:00 those pro-inflammatory cetto kindes that can inhibit the mitochondria from doing this job effectively and then there's also there is some evidence to suggest as well it may help with Browning uh meaning helping with the white adapost tissue going into the brown adapost tissue as well in animals that they've shown that as well so surrounding the world of of inflammation right like I think that people have a tendency to maybe think that inflammation is something that's only going to happen if you're uh you know maybe metabolically deranged or you're older and you know
08:00 - 08:30 for example I've had states where I know I'm in an inflamed state but if I measure my like C reactive protein my cardiac CRP is fine right so it's like for people that are trying to understand like okay am I inflamed like do I need better recovery like what markers do you really look at do you recommend people look at because like CRP is just such you know it's one not it doesn't mean everything right like you can be young have a like I have like almost undetectable CRP but I know that like there's times when my creating K's levels are super high I know I'm
08:30 - 09:00 inflamed I'm beat the crap out of my body right so what can people look at maybe more objectively that are a little bit more in tune so they they actually have these cyto kind analysis now the problem is they're not super accessible meaning most Labs don't offer them but there are very specialized labs in the US that do offer them and they can measure like Incan 6 tnf Alpha and a bunch of other pro-inflammatory cines and give you a much more specific gauge of if these different cyto kindes are elevated because that will give you a nuance picture of if you're in a
09:00 - 09:30 potentially if you're in a pro-inflammatory state or if you're producing more of these inflammatory signals than you should be uh and then in terms of CRP there's actually they have technology now where uh some of the agent companies like the generation lab which we talked about in a previous podcast that basically measuring the biological noise and they can measure inflammation at a cellular at a nuclear level so meaning they're measuring CRP methylation uh and essentially that's a way to look at the cell that cell itself to see how inflammation is being
09:30 - 10:00 expressed interesting so it's almost like does it act as more of like a like a lagging indicator I mean like so in a way like it's interesting like it be nice if we could have sort of the hba1c of inflammation right because that's the issue that I always have with you know you're getting it's a snapshot in time yeah right like and it's like I would imagine that inflammatory signaling is is is rapidly changing at different times and it's like to be able to have an idea of like hey how's this actually affecting you at like a nuclear at a cellular level yeah no exactly so this test the generation lab one I a you can
10:00 - 10:30 tell I'm a big fan of it but the reason I'm a big fan of it because one of the one of the they have like 19 different age kind of organ systems that they measure and one of the kind of organ systems that they do is in inflammation and so they can tell you your inflammation over time again with interventions and then see how much inflammation there is in your body at a more like a DNA level that's really interesting yeah that's something that I think I wish more people would kind of be in tune with at a younger age because I feel like you you know I don't want to say once the damage is done it's done
10:30 - 11:00 it's not really the case but if you can kind of have an idea of where you're at or where not necessarily even an intervention but going the other way like okay this kind of training is detrimental or and being able to connect the dots like I'm always in a world of connecting the dots and trying to like okay that were I felt really good that day so let me try to reverse engineer how I lived that way but I have nothing objective other than the fact that okay I ate broccoli the night before I did hit I did some bfr training and my brain was turned on okay I'm going to repeat that cycle repeat it didn't work okay
11:00 - 11:30 you know so it's like how do I objectively know like what's impacting me in a positive way so that I can sort of replicate that and understand my lifestyle yeah exactly and I and I haven't I haven't found that there are companies out there for example that will say hey based off your genetics you should do this type of exercise but I haven't found those to be particularly helpful because it doesn't it doesn't actually measure objectively if that's change if you you don't have an objective way to say it's just saying based off okay your genetic pool based off like your ANC hist that this is the
11:30 - 12:00 type of exercise that's probably best for you and I I personally haven't found those to be super helpful whereas I found this like way of objectively saying hey this intervention is actually making a difference at a C Level that's much more of a way to kind of Auto regulate your training yeah so would you say like um you know you obviously have looked at lots of different people lots of like what would you say sort of the common denominator is for people that this is going to sound very broad but for people that are healthy with good body composition I mean after treating
12:00 - 12:30 lots of different people you say okay like hey it's people that live this lifestyle people that live this lifestyle like what are the kind of the common denominators if I had to ask you your opinion so I think by far the the biggest thing I see is their abil I mean just the world we live in I think their ability to deal with stress is one of the biggest biggest things so being able to have that stress resiliency and being able to not only have like coping strategies but realizing that if a lot
12:30 - 13:00 of people have this unresolved emotional trauma that they deal with and they think that doesn't affect their nervous system they think it doesn't affect their ability to train or recover uh but it but it can and it does and so working through that whether that's through you know EMDR there's Vegas nerve stimulations there's there's all these different like things out there now that you can do to deal with it and I I think a lot of people don't put the two and two together because they realize that the the you know the obviously the Mind Body Connection and kind of the the mental state of your body and your nervous system Readiness it can be affected by by that you know in terms of
13:00 - 13:30 how you train I want to double click on the Vegas Nerf stuff for just a second because I think that has a very strong just as you mentioned correlation between someone's ability to build muscle burn fat recover all this stuff it matters it does matter what what do you mean by like what kind of therapies treatments do you do for for the Vegas nerve yeah so we actually inject directly into there so so the Vegas nerve is a gateway to your parasympathetic nervous system it's also the fastest think of it of a highway from your brain to your gut so it's like fast fastest way your brain communicates
13:30 - 14:00 to the gut directly and then there's also fibers that go to your heart to all your organs really and so what can happen is when your vus nerve or your nervous system becomes disregulated it can kind of send the send the wrong signals which can lead to cortisol disregulation it can lead to this fight ORF flight kind of response all the time or easily for a lot of people and it can lead to sleep issues like and it can lead to issues with recovery so a lot of it can create a lot of different problems in that sense and so what we're trying to do is trying to restore balance in the nervous system so think
14:00 - 14:30 about it this way if your parasympathetic nervous system is not functioning properly then we want it to upregulate so we want to increase the function of it and that's why there's these people have probably heard of like Vegas Nerf stimulators they've become more and more popular recently and the reason is because they're trying to stimulate the vegus nerve right externally and they're putting like electrical signals in there toci to say hey start firing better but we're going in there with the needle directly and we're not touching the vegus nerve but we're injecting around it and we're injecting exosomes and peptides uh which are basically signals to upregulate the
14:30 - 15:00 function of it and then the sympathetic nervous system there's something called a Stell ganglion block this is well established kind of procedure that's been around for over 20 years has been used for trauma and basically what it does is it calms down the sympathetic nervous system and we're not again we put a little bit of a Twist on it because we're not just putting anesthetic we put peptides as well uh because the peptides as your audience probably knows can have a modulatory effect that can reprogram cells as opposed to just blocking them so does the if the the Vegas nerve
15:00 - 15:30 you're constantly in a state of like Fireflight right so is it in effect just like an overstimulation where it's just turned on all the time is that kind of what's going on so it's actually the sympathetic gangon is turned on all the time so the sympath is a sympathetic chain and the Vegas nerve is not turn on enough the Vegas nerve is the relaxation Gateway and the sympathetic is kind of that fight ORF flight got it so is that where um kind of the influence of like serotonin in the gut versus the brain cuz Ian that's where I don't know if you're familiar with this or if you're Savvy in this but where I've always
15:30 - 16:00 gotten a little bit confused is that like from what I understand the serotonin in the gut can't cross the bloodb brain barrier but it does still impact the that pathway it does so are you familiar with kind of how that works yeah well also the gut is responsible for 2third of the molecules in your blood either directly or indirectly by affecting their synthesis crap yeah so so basically your gut has its own the microbiome and kind of the way it functions is going to affect what
16:00 - 16:30 everything in your body essentially because so it's not just like gut brain access or something called the gut pancreas access or something called the gut dis access meaning the gut communicates with even chronic back pain gut joint access so it's not just like because most people have heard of gut brain access but people don't realize the gut communicates with all your different organ systems throughout your body and it has its own it's like its own little brain right it has its own little nervous system as well the entric nervous system dude that's like you have no idea all the like the light bulbs that are going off in my I um not to digress and I've talked about this a number of times like I got a gnarly
16:30 - 17:00 parasite last August and um you know so like things were just disregulated things were messed up right like seven ulcers and it was just like huge gut permeability issues like very bad inflam that was the only time my CRP has ever been elevated in my life like it was a clear like line of connection there also coincided with like the worst back injury I've ever worst I've ever damaged my back in my life I've always had lower back issues and it was just like was not recovering once I was able to kind I get the gut healing in check the back
17:00 - 17:30 started to heal right it was like it was it was impossible like why is this not healing but it was also coinciding with it so it's like no one's ever made that connection before so just for a second though so it literally like there's the and so you said it's the it's the gut disc access yeah how does that work so there's something called lipopolysaccharides which is basically a type of uh bacteria that can translocate from the gut into the disc and because you get intestinal permeability AKA leaky gut there exactly and then it can
17:30 - 18:00 actually go directly into the disc and then what does it do when when that bacteria goes into the disc what does it do it creates pro-inflammatory signals is what's called endotoxemia uh this is actually prevalent with many chronic diseases and it's because where does the problem start though it starts in the gut and that's why fixing the gut lining is so important the intestinal permability but also having the right gut microbes that's why gut dysbiosis is one of the Hallmarks of Aging there's like 12 Hallmarks of aging and that's one of them and the reason is because it's so important it's under factor in driving so many chronic
18:00 - 18:30 conditions it's it's CU it's like it's now pretty well estab very well established I mean even even the most like I say with quotes like evidence-based people the people that like are just you know yeah like they just like they won't look at anything unless there's an rcct like even those people are saying like Okay the link between emotional stress and back pain is very clear now right okay well then you look at the link between the gut and emotional stress the gut and the back it's like okay well that's where do we start then is it yes the emotional
18:30 - 19:00 stress the emotional stress impacts the gut and like perhaps that's the actual Link versus the fact that you know there's a lot of very direct linear ways people look at it oh well when you're emotionally distressed you're more tense okay well I'm more inclined to think when you're emotionally distressed you're guts out of whack and thus Begins the physiological response yeah no that's that's my conclusion as well and that's why I'm a huge fan of FAL microbial transplant uh fmt uh which we're manufacturing and we'll have but to make it more accessible but fmt is basically transplanting new microbes
19:00 - 19:30 into your gut as the name suggests and this is a procedure that's been around for a while but still if you want to get it it's not super accessible because you have to do it through colonoscopy and it's also you know fairly very expensive and they won't do it for you in the US unless you're basically failed every other treatment and you have a like ulcer of colitis or something really overtly gut related because they think they still think everything is just unless it's a gut problem they don't won't treat the gut that that's they're still thinking the old medicine basically I have a
19:30 - 20:00 friend that went to Turkey had to go to Turkey to get it done and uh it was like they were dealing with I mean it was like serious ulcerative colitis like really really bad and that was like one of the only kind of last ditch efforts and it worked yeah but it's kind of sad that he had to go to Turkey yeah it's uh and you see it obviously we talk about FAL transplants like in rodent model research all the time right where they'll take uh you know a feces from a an obese human and put it in like a germ-free mouse and the mouse becomes obese it's like okay show me how that is not something that matters well
20:00 - 20:30 in in humans they've actually done this so there was a Taiwanese gold medalist who happens to be a microbiologist so she did her microbiome sequencing and they found a bacteria strain in her and many other highlevel Olympic gold medalists or Olympic medalists they have this o they named it o1 and so they take that bacteria strain and they transplanted it into nonathletes and those non-athletes actually increased their cardiovascular fitness they got and their cardiovascular capacity
20:30 - 21:00 improved so how crazy is that that's same one with have you heard of villanella before same same different strain but same kind of thing except it was more uh like Ultra Runners it was endurance Runners it was uh you know sub three-hour marathon runners so it basically same kind of thing like okay so so the plan for us is to create fmt our first generation fmt is it's it's Lio it's lopi so freeze dried capsules so it bypasses the stomach and it can survive and go into the small intestine so it's going to make it a lot more scale aailable and accessible that way
21:00 - 21:30 so essentially but but it actually does something the problem with probiotics is they're transitory they don't actually repopulate the gut uh most of them and so this is actually going to repopulate the gut with new microbes and that the first generation when just kind of like a general like longevity let's say fmt uh and for health but then eventually we're going to have like specific ones where we have like we literally get Olympic gold medalist that's Co and then we'll have an fmt for athletes and that'll be I think that'll be very exciting product you know what's funny
21:30 - 22:00 is I've always joked on this channel like for years people that watch my channel for a long time know that like I've said like if you tell a bodybuilder to eat a dog turd because it'll make them Jack they'll do it like it's like they'll do anything um but what's funny is I don't know if there's any veterinarians watching but I've had uh like I know in the animal world it's I don't know if it's legit science or not because that's not the world I'm in but I've heard that dogs that go in their backyard and like eat poop a lot of times know inherently that they need something different and that so it's
22:00 - 22:30 because it's obviously problem smell is it's like where they're they're in tune with like okay I need so they'll go eat the other dogs poop to try to actually do something and so so the next time my dog eats poop I won't yell at him yeah maybe he just knows what's up maybe he's let him do it and he'll get jacked uh well Dr KH where can everyone find you man yeah so Instagram at dr. Aon khn and then our website is eta. health so e t r na a. Health right on my man thanks brother thanks for having me