Schulz Reacts: Neuroscientist Dr Huberman Explains PEPTIDES

Summary

In this episode of Flagrant Clips, neuroscientist Dr. Huberman covers the increasing interest in peptides as a middle ground between supplements and prescription drugs for health and fitness. Emphasizing essential lifestyle habits like sleep, exercise, and nutrition, Dr. Huberman explains how peptides like sermorelin and bpc157 can boost growth hormone release, assist in recovery, and support fat loss and muscle repair without significant risks to fertility. He also touches upon the importance of clean sources and medical supervision when using these substances, while highlighting ongoing developments in testosterone replacement therapy (TRT) and the broader implications of performance-enhancing substances.

Highlights

• Peptides sit between regular supplements and hardcore drugs, providing a smoother way to enhance your body goals! 💡
• Get your sleep and diet right before considering peptides for that extra boost, says Dr. Huberman. 🛌🍎
• Sermorelin injects a nightlife of growth hormone into your system, aiding recovery and fat loss. 📈
• Mind the source! Buying peptides legally ensures you avoid sketchy sites with dubious products. 🎯
• TRT isn't just a free pass to more testosterone; watch out for fertility and ensure consistent medical guidance. 🚨
• Lots of Hollywood and athletic bodies are on the peptide bandwagon to maintain that perfect look! 🌟
• Watch out for the potential downside—unwanted growths accelerate too; caution and cycles advised! ⚠️

Key Takeaways

• Peptides are a trendy middle ground between supplements and prescription drugs boosting health and fitness! 💪
• Dr. Huberman advises on the significance of foundational habits like sleep and proper nutrition before diving into supplements or peptides. 💤🥗
• Sermorelin and bpc157 peptides can aid in muscle repair, libido enhancement, and fat loss without harming fertility. 💥
• Always ensure you get peptides from a clean and legit source to avoid dangerous impurities. 🧪
• TRT and peptide discussions should involve a doctor's supervision to avoid long-term health risks. 🩺

Overview

In a lively discussion with Dr. Huberman, the topic of peptides takes center stage as an intriguing option for enhancing health and fitness. Unlike the typical supplements or severe steroidal drugs, peptides like sermorelin provide growth hormone benefits without a prescription requirement, although sourcing them through a doctor is safer. Dr. Huberman shares his personal experience using sermorelin to improve sleep and recovery, likening its effects to the revamped bodies seen in Hollywood.

Apart from sermorelin, bpc157 emerges as another peptide gaining popularity. Based on a natural gastric peptide, bpc157 accelerates healing of tissues, making it a favorite among athletes for injury recovery. Dr. Huberman cautions against cancer risks due to growth stimulation, recommending periodic cycling of these substances to avoid continuous exposure. Although peptides are beneficial, Dr. Huberman urges dependence on sustainable health habits first and foremost.

Discussing the future of testosterone replacement therapy (TRT) and its evolving practices, Dr. Huberman warns against starting too young. The right balance of natural hormones through conventional exercise and diet is emphasized, leaving peptides and TRT as secondary options for those needing extra help. The conversation underscores the careful balance required when using performance-enhancing substances, with awareness of potential addiction or health pitfalls.

Chapters

• 00:00 - 00:30: Introduction to Peptides The chapter introduces the concept of peptides, explaining that they are simply chains of amino acids. It emphasizes the importance of foundational health practices such as proper sleep, exercise, nutrition, and social interactions. These are essential for optimizing testosterone levels, muscle growth, fat loss, and overall health. Additionally, the chapter briefly mentions the role of legal supplements like Tonga Ali and Fedogi aggressives that can support these health goals.
• 00:30 - 01:00: Supplements and Prescription Drugs The chapter discusses the use of supplements and prescription drugs in enhancing testosterone and growth hormone levels. It differentiates between general supplements that can mildly boost testosterone without shutting down natural production and prescription drugs designed for testosterone replacement therapy. The discussion extends to the potential abuse of such substances, including steroids like Anadrol and Oxangelone, which are associated with a distinct physical appearance. Finally, the chapter hints at a new trend or 'wedge' in this domain, suggesting evolving practices or compounds.
• 01:00 - 02:00: Peptides: A Middle Ground The chapter discusses peptides, specifically focusing on their role as a middle ground between supplements and prescription drugs. It introduces various kinds of peptides, particularly those popular in health and fitness for both males and females. The chapter highlights secretagogues, a type of peptide that stimulates the release of growth hormone, mentioning examples like sermoreline. These peptides are notable for being injectable and obtainable without a prescription.
• 02:00 - 02:30: Benefits and Risks of Peptides This chapter explores the benefits and risks of peptides, particularly focusing on their ability to stimulate massive growth hormone release and factors like IGF-1, which aid in faster recovery, fat loss, muscle repair, and increased libido. The discussion touches on the prescription requirements for peptides such as sermorelin, which can significantly boost these effects. The chapter also notes that using these peptides does not interfere with fertility or efforts to conceive a baby.
• 02:30 - 03:30: Sermorelin and Its Uses The chapter delves into the effects of testosterone on sperm production and discusses ways to counteract these effects, such as using HCG (Human Chorionic Gonadotropin) to stimulate the testes to continue sperm production. It highlights how HCG used to be sourced from pregnant women's urine before laboratory production was implemented, and mentions its usage in bodybuilding communities.
• 03:30 - 04:30: BPC-157 and Healing The chapter discusses the topic of BPC-157 and its role in healing, though the current transcript focuses more on the discussion of various substances related to fertility and testosterone use. It touches upon the black market for pregnant women's urine due to its fertility benefits and contrasts it with substances that do not require prescriptions, albeit being seen as sketchy options. The emphasis is on the intricacies of sourcing such substances, with some requiring prescriptions and others being available through unreliable sources.
• 04:30 - 05:30: TRT and Testosterone The chapter discusses the gray market of testosterone replacement therapies and the challenges in ensuring purity. It highlights the illegitimate ways, such as using Venmo with different names, to obtain such substances. Readers learn about prescription drugs like Sermorelin, which the author openly admits to using to improve sleep and increase IGF-1 levels, denoting openness in discussing usage to avoid speculations about being 'natty' or natural.
• 05:30 - 06:30: Balance and Natural Approaches The chapter "Balance and Natural Approaches" appears to involve a conversation about recovery from exercise, age-related aspects of physical fitness, and humor around professional cycling and steroid use. While the speaker notes a personal late start to regular exercise at the age of 45, they compliment someone for their current fitness, humorously comparing their appearance to a well-known cyclist associated with steroid use, Lance Armstrong. The chapter hints at themes of honesty and integrity as the speaker makes a reference to the athlete's eventual confession regarding steroid use. However, humor and caution are present in the discussion, avoiding deeper comment on controversial topics.
• 06:30 - 07:30: Women's Use of Peptides and Sports This chapter discusses the use of peptides by women in sports. The transcript touches upon the general perception of a sports figure referenced through wristbands, most notably Lance Armstrong and the 'Live Strong' campaign. It touches on societal shifts towards a more honest representation, reflected in the rejection of wearing such wristbands. The focus shifts to peptides, detailing their side effects, particularly the growth they can induce. It warns that while they can promote muscle or healing, if someone has an underlying health issue, such as cancer, peptides could exacerbate the growth negatively, making them a controversial choice.
• 07:30 - 08:30: Sources and Safe Use of Peptides Peptides are commonly used in Hollywood to achieve the desired body aesthetics, focusing on definition rather than size.
• 08:30 - 10:00: Club Drugs and their History This chapter discusses club drugs and their history. The transcript mentioned a substance called BPC-157, which is based on a gastric peptide known for promoting tissue healing. Although not extensively studied, BPC-157 has been used for its healing properties, as shared by someone's personal experience of recovering from an L5 compression. The chapter suggests that while other treatments like massage and heat therapy are employed for healing, BPC-157 provided significant pain relief post-injury.
• 10:00 - 11:30: Comedy Scene and Drugs The chapter discusses a scene involving comedy and drug references, particularly focusing on bbz157, a substance that gained attention when an athlete used it to recover from an Achilles injury before the Olympics. The conversation highlights the importance of obtaining drugs from reliable sources and notes that there are physicians who can legally prescribe them. Additionally, the chapter reassures that such substances are not known to negatively affect fertility or testosterone levels, nor do they seem to have notable adverse effects according to the current awareness.

Schulz Reacts: Neuroscientist Dr Huberman Explains PEPTIDES Transcription

• 00:00 - 00:30 peptides just means a chain of amino acids um but let's just get this um out so because there's a lot of interest in this now um right you need to sleep exercise good nutrition uh good social interactions you need to do all that stuff right you're never going to optimize testosterone muscle fat loss Etc if you're not doing those things you need to everyone needs to do that then there's a question of like supplementation and there are some good supplements that are legal things like Tonga Ali fedogi aggressives they can
• 00:30 - 01:00 boost testosterone somewhat um and that people get benefit from and don't shut down your own testosterone production or growth hormone production then there are drugs prescription drugs like growth hormone testosterone that people use for testosterone replacement therapy and then just all out steroids like Anadrol Ox angelone where like you see the guys you know the look right I mean you know yeah um you know and that can be abused Etc any of those things could be abused but but there's this new kind of wedge in
• 01:00 - 01:30 between supplements and prescription drugs that are called peptides and they're a bunch of different kinds and the ones that are most popular right now in health and fitness it for use in both males and females are for instance things that stimulate the release of growth hormone they're called secretagogues that sounds like synagogue but it's secret agog things like sermoreline they all you take it as an injection they can be bought without a
• 01:30 - 02:00 prescription or with a prescription we can talk about what's better um and they're taking before sleep if you haven't eaten anything for a couple of hours they stimulate massive growth hormone release igf-1 Etc they help you recover faster fat loss muscle repair they also stimulate libido pretty pretty this is America yeah what is this sir morellin why are we not all how can we well okay a couple of reasons one to get it really good sermoreline in your prescription but there are lots of doctors that will prescribe work on that yeah what if I'm trying to have a baby does that [ __ ] that up it does not
• 02:00 - 02:30 disrupt so testosterone will disrupt sperm production you can offset that so let's say you were to take testosterone um it would shut down your own sperm production testicle shrink some people more than others but some people will take HCG human chorionic and additropin that can stimulate the testes to continue to make sperm HCG incidentally used to be now they make it in a laboratory you inject it used to be um collected from pregnant women's urine so in the bodybuilding Community people used to live really like try and drink
• 02:30 - 03:00 pregnant women's urine there was a black market for it yeah I knew that yeah I figured that story was going to widen somebody um but did you notice I went in yes exactly so people can maintain fertility on uh testosterone but sir morellin will not disrupt fertility um why wouldn't you take it okay well there is this issue that first of all you need a prescription to get it clean there are sources online where you can just buy it without a prescription it's a little sketchy you go to these sites
• 03:00 - 03:30 and they're like they say venmo me but venmo me under this name so it's kind of gray Market the problem with those is you don't know about the Purity you don't know if you're getting what you think let's assume that we have some connections we can get MDS will prescribe us for Moreland yeah I've used sermoreland before I actually still listen I'm really open about this because I never want to be like a Natty or not video on me I'll just say like not you know I mean not meaning I'm I take some Moreland about three or five nights a week um helps me get into really deep sleep quickly you get a bit of a IGA F1 boost
• 03:30 - 04:00 it's great you recover I never recovered very quickly from exercise I didn't start until I was 45. um you look great now you look like what I thought Lance Armstrong would look like with the steroids I ride a bicycle but not like him um uh there's another joke there but I'm not going to make it what is that no no no no no no no um I had to be careful um I never met Lance I'm sure he's a nice guy there's a guy who eventually eventually came clean about his and
• 04:00 - 04:30 people still seem to like him they don't wear The Wristband though it took a while but wristband's gone yeah we came around yeah instead of Live Strong and sort of like live honest and by not wearing The Wristband yeah sorry Lance um okay the downside is it causes growth of all things right so if you have for instance a small cancer growing on your pancreas it will accelerate growth of that cancer now so you tend to want to
• 04:30 - 05:00 cycle these things doing infrequent use you know five nights a week or three nights a week or occasional use you know look I'll tell you right now a lot of the bodies you see in Hollywood films are on peptides because right now the look isn't really super huge oh like 80s professional wrestling yeah the look is you know the women are a little bit leaner and stronger than in past years the men are sort of in that middle range you know it's more about definition and you know okay um sir Moreland then there's also
• 05:00 - 05:30 something called bpc157 which is actually based on a gastric peptide turns out that there's a gastric peptide that we all make that can promote healing of tissues and I've talked to Joe a lot about this they're not a lot of data on this whereas there are a lot of data on sermorelin but bpc like I had a L5 compression and I was always like in pain standing up from a dumb thing I don't deadlift anymore I just made a dumb mistake um in terms of form and massage Heat their electric therapy the whole thing two injections of bpc157
• 05:30 - 06:00 look if it was Placebo okay I'll take it gone gone BB and the bbc157 is remarkable a few years ago a guy um tore his Achilles right before the Olympics came back bbz157 was implicated in that so again you want to get good clean sources there are Physicians that will prescribe these again these aren't going to shut down fertility or testosterone production um and then there's kids wonky or anything like that not that we are aware of not that we're aware of your kids are
• 06:00 - 06:30 going to be okay your kids are just gonna have so much fire in them you know what I need to take something so I have someone to blame it on when my kids you're going to raise them in New York it was not peptides yeah you're gonna raise them in New York I hope I don't know you know we'll see I think it was the late Philip Seymour Hoffman that said in his will that his kids wouldn't get any money if they lived outside of New York or Chicago or London because he
• 06:30 - 07:00 wanted their brain to develop in a sensory Rich environment is that where he grew up because I'm going to raise my kids in a different place no he he unfortunately tapped out through unfortunate circumstances but I think there is something having that intensity you know I mean kids from who aren't from New York they come here and they hear a siren go by and they're like you know my niece grows up in a big city and she's like totally comfortable in noise and Chaos she's super calm I see the kids here they're just like whatever you know it's like they just can cope you take a kid like that you put them in
• 07:00 - 07:30 California and they're going to run the company yeah because there's just they have so much energy and so much force yeah you know and everyone else is like dissolving into a puddle of Tears because it's so much we're staying here all right um so okay so there's BP's there's sir Moreland there's bpc157 there's and then there's this whole landscape now of like tb500 Etc there's a lot of kind of um cocktails of peptides I know less about that um and they're far less data on that now as long as we're having this discussion
• 07:30 - 08:00 because of this audience I have to assume has heard of trt and testosterone replacement there's a lot evolving there I'm hearing about guys going on really young I really worry about that because it will shut down your sperm production unless you won't be able to conceive kids unless you're doing something to offset that like taking HCG and that should always be done with a doctor the new way of doing this is not to get one shot every two weeks of massive testosterone but taking smaller doses every third or fourth day dividing that up and then doing the HCG as well that's
• 08:00 - 08:30 very common but trt you know the r is replacement therapy and the range of testosterone is really Broad and I what I would think I what I think guys should do is I started weight training when I was 16 started I was running and weight training and then when I got to Santa Barbara I was more like weight training and hanging out a bit and then I got serious about studies but the point is that you want to train on your own hormones get learn good sleep good nutrition good habits and also live your life right you're not gonna like not have a beer or two every once in a while
• 08:30 - 09:00 at age 22 just because you might not recover as well like okay if you have a tendency towards alcoholism be careful but you know let's live your life is my my uh stance but once you have all those things in place let's say you already have kids and people are feeling tired and more sluggish than testosterone replacement therapy can make sense for some people the problem is a lot of people think of a little less good more is better and that's not and that's not good and also it's what you do with that you still have to run eat well yeah you know preserve your cardiovascular health yeah
• 09:00 - 09:30 it doesn't replace those they still need blood work to make sure your prostate antigens aren't going crazy and stuff like that yeah I hear about young guys who are just like you know they're slamming Viagra and testosterone it's like this and that that's not gonna play out very well over time right like see what you can do naturally with hard work and dedication and balance yeah and then over time you can explore things but the peptides are interesting they're kind of a you know Middle Ground where you're not risking as much in terms of long-term fertility issues um they're not going to they're not going to give you a ton of acne or
• 09:30 - 10:00 something or you know make someone look crazy um like they could if they abuse steroids and women are using them a lot more now because they're milder they don't have these so-called androgenic effects they're not going to deepen The Voice they're not going to create facial hair for women that kind of thing but yeah they certainly work they're abandoned sports for a reason although last night I don't want to get beat up by any of the MMA trial but I can look at some I mean some of the athletes are either genetic freaks or they're using in the
• 10:00 - 10:30 offseason I mean I think I've seen some photos of Conor McGregor now I mean he's big yeah he's big so either he has ridiculous genetics yeah or he's on something listen no shame in that I mean it's his life he can do what he wants yeah um you know there's a runner who ran for Stanford I think still holds the American record for Marathon for fastest U.S Marathon Ryan Hall he was like a stick finished running got out started lifting weights he's a beast looks like something out of a Marvel movie really mostly because he's just eating and dead
• 10:30 - 11:00 lifting and squatting now he still runs a little bit but he's not running yeah gazillion miles a week yeah yeah dude yeah so the peptides are interesting but make sure you get a clean Source there's some good sources like tailor-made you need a prescription is a good Pharmacy for peptides these are cleaning because you don't want to go to where the guy you get yours from yeah I mean I can I can definitely I mean I mean I can give up I mean listen there there is a physician who's doing this kind of work online yeah but and it's not illicit you know I
• 11:00 - 11:30 mean he'll make you do blood work and that kind of thing yeah but I'll do I do take sermoreline about three to four nights a week you can't take it every night because it has less of an effect um now and then there's this whole landscape of gray Market in the old days we're not doing that [ __ ] yeah in the old days it was the big drug out here um in the club scene was GHB gamma hydroxybutyrate which increased growth hormone that's what River Phoenix that's the date rape drug right uh that's Rohypnol Rohypnol yeah isn't that GHB
• 11:30 - 12:00 GHB uh no GHB stimulates growth hormone release it's a hypnotic and it was big in the club scene and then it became big in the kind of sex club scene um and then when River Phoenix died it became implicated in that and they actually used to be able to buy it at GNC get the [ __ ] yeah but not anymore so they but it turns out River Phoenix you know sadly had a heroin cocaine marijuana alcohol um and GHB in his system which is obviously you know very you know is that poppers what's poppers uh poppers I
• 12:00 - 12:30 think were something of I don't know you know what the two drugs that totally disappeared are are Quaaludes and poppers yeah quailers are gone Quaaludes I don't even know what a quaalude is me neither but it looked fun in that actual finite supply of from Wolf of Wall Street which I rewatched recently great movie but they're they're gone because people just took them all and it was supposed to I think help you sleep or something but then I found out if you stayed awake past a certain point you
• 12:30 - 13:00 got super high and it got fun that sounds like GHB and remember ketamine used to be a recreational drug right um yeah all these drugs that listen if people are gonna exploit with a medical doctor I'm not saying that to protect me I'm saying that to protect you being in the audience like you have to these are not things you want a cowboy especially with all the fentanyl stuff happening now is is so crazy I mean you just die the first time that just yeah because I remember growing up they said if you smoke crack once you're gonna be
• 13:00 - 13:30 addicted for Life remember that was the public message um it does seem like you can die from fentanyl first time yeah yeah sorry to go dark there but always happening to a bunch of comedians yeah yeah really yeah yeah is it true that comedians they thought there was cocaine is cocaine in the comedy scene I think it was huge in like the 80s yeah and I think for sure it's still a little bit more in LA and stuff like that cocaine is just like uh or it was before this fentanyl stuff it was just a
• 13:30 - 14:00 recreational drug I was surprised I mean I'll be honest especially like younger people how often they were using it it was just like every weekend it was like smoking weed drinking alcohol I feel like when I went to college there was some people smoked some pots maybe some psilocybin use but it was really just alcohol yeah it wasn't for Santa Barbara it wasn't a big um cocaine scene or heroin scene I'm sure there were pockets of that but I was never exposed to that um well yeah I think that the the peptides thing is interesting