Press-Pulse Presentation Clips of Dr. Seyfried & Dr. D'Agostino (Supercut)

Summary

In a captivating discussion, Dr. Thomas Seyfried and Dr. Dominic D'Agostino present their innovative Press-Pulse therapeutic strategy for managing cancer. This strategy focuses on disrupting cancer cells' energy metabolism by using a combination of dietary management, stress reduction therapies, and various inhibiting drugs. They argue that cancer is fundamentally a metabolic disease, not a genetic one, and propose methods like ketogenic diets, hyperbaric oxygen therapy, and glucose and glutamine inhibition as effective treatments. With a strong emphasis on non-toxic therapies, they envision a future where these methods replace traditional cancer treatments.

Highlights

• Dr. Seyfried and Dr. D'Agostino propose a new cancer therapy approach focusing on energy metabolism. 🔬
• The Press-Pulse strategy combines ketogenic diets, exercise, and stress management. 🥗🏋️‍♀️
• Metabolic therapies target cancer cell vulnerabilities, such as glucose dependency. 🎯
• Hyperbaric oxygen and ketone supplementation are crucial components of this therapy. 💥
• Real-life cases show patients achieving better health and longer survival with these methods. 🌈

Key Takeaways

• Cancer is viewed as a metabolic disease, not a genetic one, emphasizing energy metabolism management. ⚡
• The Press-Pulse approach integrates ketogenic diets, stress reduction, and metabolic therapies. 🍽️🧘‍♂️
• Combining glucose and glutamine inhibitors with hyperbaric oxygen therapy may improve treatment outcomes. 💪
• Emphasis on non-toxic treatments aims to reduce the side effects of standard therapies. 🚫☣️
• Dr. Seyfried and Dr. D'Agostino envision these methods making traditional cancer therapies obsolete. 🌟

Overview

Dr. Seyfried and Dr. D'Agostino unveiled a groundbreaking cancer treatment strategy called the Press-Pulse approach. This method aims to manage and resolve cancer by targeting the disease's energy metabolism rather than its genetic aspects. By combining strategies like ketogenic dieting with targeted metabolic inhibitors, the pair hope to provide a more natural, non-toxic way to combat cancer and improve patient well-being.

The methodology behind the Press-Pulse approach involves cycles of ketogenic diets and therapies like exercise, music, and yoga to manage stress and improve patient outlook. These are paired with therapeutic fasting and drugs that inhibit glucose and glutamine, crucial nutrients cancer cells rely on. The approach also leverages hyperbaric oxygen therapy to enhance the potency of these treatments, representing a potentially new standard of cancer care.

Highlighting real-world successes, the duo shared compelling stories of patients in different regions who have undergone this treatment with remarkable results. These cases illustrate substantial improvements in health and survival rates. Dr. Seyfried and Dr. D'Agostino strongly argue that this metabolic-centric approach will eventually replace conventional therapies, as it fundamentally changes the understanding and treatment of cancer.

Chapters

• 00:00 - 00:30: Da Vinci's Symbol and Cancer Strategy Introduction In this chapter, the authors discuss their paper that is currently under review, which outlines a strategy for managing and potentially resolving metastatic cancer. They use Da Vinci's Vitruvian Man as a conceptual model for their approach. The chapter focuses on the methodology they propose for dealing with metastatic cancer, regardless of whether it affects the colon, breast, or brain.
• 00:30 - 01:00: Cancer as a Singular Disease of Energy Metabolism The chapter discusses the concept of cancer as a singular disease, emphasizing the point that all tumor cells behave as part of the same disease due to their reliance on energy metabolism through fermentation. It suggests treatment strategies that focus on manipulating this energy metabolism, such as utilizing ketogenic or paleo ketogenic diets, among others, which can be tailored based on individual response. The chapter hints at the importance of ‘press-pulse’ therapies that strategically manage the disease by pressing on metabolic weaknesses of cancer cells.
• 01:00 - 01:30: Diet and Stress Management in Cancer Therapy The chapter discusses the significance of diet and stress management in cancer therapy. It highlights the importance of fat composition in the diet, specifically mentioning the role of ketone supplements. Stress management is emphasized as a crucial factor in cancer recovery. Patients often experience emotional distress, including depression, and managing this stress is vital for their recovery. The chapter notes various therapies that can aid in stress management, such as exercise therapy, yoga therapy, and music therapy.
• 01:30 - 02:00: Press and Pulse Therapies Overview The chapter discusses various therapies aimed at reducing physiological stress in patients, helping them feel better and remain actively involved in managing their diseases. It introduces the concept of 'press and pulse therapies,' which include glucose inhibition as a key component. Techniques involve dietary glucose reduction and pharmaceutical interventions using drugs like 2-deoxy-D-glucose. The overall goal is to support patients' wellbeing and disease management.
• 02:00 - 02:30: Dosing, Timing, and Scheduling in Therapy The chapter discusses the strategy of dosing, timing, and scheduling in therapy. It includes considerations on how much dosage to use, when to administer it, and for how long the treatment should be maintained. The chapter also mentions glutamine inhibitors, giving an example of 'dawn' to test hypotheses, and highlights the role of hyperbaric oxygen in pulse therapies.
• 02:30 - 03:00: Press-Pulse Approach and the Glucose Ketone Index The chapter discusses a novel therapeutic strategy for the metabolic management of cancer called the "Press-Pulse Approach" and its relation to the Glucose Ketone Index (GKI). The strategy proposes scheduling certain therapies and adding others between them to enhance the health and vitality of the patient, with the ultimate goal of making traditional cancer therapies obsolete. The approach is based on understanding the biology and biochemistry of the cancer system.
• 03:00 - 03:30: Therapeutic Strategies: Metformin and Exercise The chapter begins with a discussion on therapeutic strategies involving Metformin and exercise, emphasizing the importance of these approaches in maintaining metabolic health. The transcript suggests focusing on a regular, sustainable routine rather than relying on genetic interventions.
• 03:30 - 04:00: The Role of Hyperbaric Oxygen and Vitamin C The chapter titled 'The Role of Hyperbaric Oxygen and Vitamin C' discusses the use of the glucose ketone index, especially in the context of therapy for seizures. The glucose ketone index is calculated by comparing glucose and ketone levels; for example, if both glucose and ketone levels are equal (e.g., 3 mmol/L), the index would be one. It is suggested that maintaining a glucose ketone index between one and two is therapeutically beneficial according to animal model studies, particularly for managing seizures.
• 04:00 - 04:30: Animal Models and Human Applications The chapter discusses various methods and strategies to target cancer metabolism. It mentions the drug Metformin as a potential continuous treatment, although there are some resistances and side effects associated with it. Additionally, the chapter highlights the role of exercise and meditation in achieving an optimal glucose-ketone index, which is referred to as the 'metabolic zone,' where glucose levels are lowered to match the level of ketones.
• 04:30 - 05:00: Outline of the Press Pulse Therapeutic Strategy The chapter discusses the 'Press Pulse Therapeutic Strategy,' which is aimed at cancer treatment. The strategy is based on the Warburg effect or phenotype, which involves metabolic characteristics of cancer cells. It emphasizes maintaining a balance to slow down cancer growth, particularly in responsive cancer types. The approach includes cyclic treatment phases described as '3 weeks on, 3 weeks off,' allowing for integration of complementary therapies, setting a foundation for comprehensive treatment plans.
• 05:00 - 05:30: Stress Management and Pulse with Drugs The chapter discusses the benefits of combining standard cancer treatments like chemo, radiation, and immune therapy with a ketogenic diet. It highlights the potential for improved patient response and reduced side effects when incorporating dietary approaches, based on communications with patients and prior research. The chapter also mentions ongoing animal model studies exploring the effects of hyperbaric oxygen therapy, drawing parallels to earlier research on brain tumors.
• 05:30 - 06:00: Patient Case Studies and Compliance The chapter discusses scientific observations regarding the effects of High Pressure Oxygen and IV Vitamin C on cells. It highlights an observation where mitochondria of cancer cells exploded while normal healthy brain cells were unaffected when exposed to High Pressure Oxygen, indicating its potential toxicity to cancer cells compared to normal cells. This was published in Neuroscience highlighting the unique reaction rather than packaging it as an anti-cancer effect. It also touches upon the role of IV Vitamin C, with David Diamond noting its function as a glucose antagonist when presented in high levels.
• 06:00 - 06:30: International Applications and Publication Challenges The chapter discusses the potential of using millar concentration as a prooxidant in medical therapies. It highlights the ability of millar concentration to stimulate reactive oxygen species production and oxidative stress through Redux chemistry and the Haber-Weiss and Fenton reactions. The chapter suggests the application of this approach as a prooxidant therapy, especially in conjunction with hyperbaric oxygen therapy, to enhance its effectiveness.
• 06:30 - 07:00: Egyptian Farmer Case Study The chapter titled 'Egyptian Farmer Case Study' discusses the exploration of using a toolbox of metabolic drugs in pre-clinical animal models to study diseases such as breast cancer, brain tumors, and lung cancer. The findings indicate that the mice involved in these studies live longer and appear healthier, prompting the researchers to develop a therapeutic strategy called the 'Press Pulse' approach. The chapter outlines this new strategy designed for potential use in humans.
• 07:00 - 07:30: Therapeutic Fasting and Surgery Outcome The chapter titled 'Therapeutic Fasting and Surgery Outcome' discusses the collaboration between George Yu, an oncologist, Joe Maroon, a neurosurgeon for the Pittsburgh Steelers, and Dominic D'Agostino from the University of South Florida. They co-authored a paper outlining the 'press pulse' concept in dieting, aimed at inhibiting tumor cell growth. The approach involves using ketogenic diets, ketone supplementation, and possibly MCT oils or ketones to exert constant metabolic pressure on tumor cells, particularly in patients with metastatic conditions.
• 07:30 - 08:00: Metabolic Therapy Effects on Brain Tumors This chapter discusses the concept that all cancers, regardless of their type (e.g., brain cancer, colon cancer), share similarities in their metabolic processes. The text emphasizes the application of metabolic therapy as a treatment, highlighting that cancer induces significant stress and anxiety in patients, especially when the disease progresses. To combat this, various stress management strategies are employed alongside the therapy, including exercise, yoga, massage, music therapy, and other forms of therapeutic support. These complementary approaches aim to alleviate the psychological burden experienced by cancer patients.
• 08:00 - 08:30: Patient Recovery and Clinic Expansion In the chapter titled "Patient Recovery and Clinic Expansion," the focus is on reducing patient stress, as high stress levels elevate cortisol and glucose, which is not beneficial. The strategy includes a combination of metabolic therapies and drugs targeting glucose levels, such as insulin and 2-deoxy glucose, along with glutamine inhibitors like chloroquin and EGCG. The use of hyperbaric oxygen chambers is highlighted instead of traditional radiation, as the former can be lethal to certain conditions while supporting recovery without the adverse effects of radiation. This approach forms part of a broader clinic expansion plan to offer advanced treatments.
• 08:30 - 09:00: Misunderstanding in Cancer Treatment and Conclusion In this chapter, the focus is on alternative cancer treatment approaches centered around metabolic therapies, specifically highlighting the roles of glucose and glutamine. The speaker questions the traditional use of radiation therapy by suggesting that managing glucose and glutamine can lead to significant patient improvement. The chapter emphasizes that many people undergoing traditional cancer treatments often have existing metabolic imbalances, like diabetes, which also improve alongside their cancer symptoms when metabolic therapy is applied. However, the speaker remains cautious and refrains from claiming these methods cure cancer, acknowledging that while patients' health improves significantly, the long-term survival or complete cure cannot be confirmed.

Press-Pulse Presentation Clips of Dr. Seyfried & Dr. D'Agostino (Supercut) Transcription

• 00:00 - 00:30 uh Dominic and I we have a paper uh that we've submitted for it's under review but we built this figure uh as an example of the strategy that we plan to use to manage and hopefully resolve cancer what I did was used Da Vinci's vran Man symbol what we did so we have an individual who's who has metastatic cancer uh and we're going to try to manage the metastatic cancer and then we're going to try to resolve the metastatic cancer whether that's colon whether it's breast whether it's brain
• 00:30 - 01:00 bladder whatever this the strategy will work because all the tumor cells are the same disease cancer is a singular disease of energy metabolism thriving on fermentation fuels so the way to to to manage the disease you have to press the and you have the pulse press therapies can involve but not exclusively restricted ketogenic diets and sometimes you don't need to restrict the diet and you can have various various combinations of the diet paleo ketogenic diets some people respond better to one
• 01:00 - 01:30 type than another Fat composition of the diet plays an important role so you need to know that Ketone supplements can be very important as a continual press on the system Stress Management is extremely important if we're going to resolve cancer people get emotionally freaked out when they have cancer believe me they get depression they get all kinds of things if you're not able to deal with their emotional stress it's not going to resolve as quickly as it could and we use what is this we use exercise therapy yoga therapy if necessary music therapy there's a
• 01:30 - 02:00 variety of different therapies that actually can reduce physiological stress and that's that we keep on the patient so they feel good all the time you want to keep their spirits up you want to keep them involved in the management of their disease and then while this is going on we then Institute press therap pulse therapies which is glucose inhibition we can take part of that is coming from the diet but we can boost that up a little bit when we use glucose Inhibitors 2 deoxy glucose fluido there's a whole range of drugs that could be applied here then we have
• 02:00 - 02:30 glutamine Inhibitors I just gave you an example of dawn okay because we were just trying to test hypothesis just to test the hypothesis so we there might be other glutamine Inhibitors that could work as well and then we have hyperbaric oxygen so we have these are all press or pulse therapies now the the strategy is called dosing timing and scheduling how much doses do we use what is the dosage when and for how long do we do this and what is the schedule all right comes
• 02:30 - 03:00 first this one that one how do we schedule this and in the intermediate periods we can add back certain therapies to en enhance the health and vitality of the person so what we're going to do is use this this is a new novel therapeutic strategy for the for the metabolic management of cancer and it is my opinion that this at in time will eventually make most other standard therapies for cancer obsolete because this is based on the biology of the system system on the biochemistry of the
• 03:00 - 03:30 system and not some genetic nonsense of the system so for future directions what we're really kind of this idea that that we've talked about and Tom sa my colleague we've written and co-author to review on this talking about this idea of a press pulse approach where a press therapeutic you know program would be a daily routine of maintaining a therapeutic keto
• 03:30 - 04:00 range of uh and Tom SE uses the glucose Ketone index if your glucose level is 3 molar and your Ketone level is 3 Millar you would have a glucose Ketone index of one if your ketones were if your glucose was four and your ketones were two you would have a glucose Ketone index of two we feel that keeping into that one to2 range if you look at all the animal model studies especially for seizures it's extremely therapeutic
• 04:00 - 04:30 and it knocks down it hits all those Pathways that I just showed you that Target cancer metabolism uh the drug met formin conceivably could be used continuously I think Tom's T are a little bit resistant against metformin it may have some side effects but exercise meditation these things can help you get an ideal glucose Ketone index which we know uh we talk about the metabolic zone so you bring glucose down to the level of ketones and ketones up
• 04:30 - 05:00 if you stay within that zone we know experimentally in animal models and I think the human data will show this and some of it points in that direction that you are at the very least slowing taking the foot off the gas pedal of cancer growth for the cancers that are responsive to uh that have the warberg effect or have a warberg phenotype we say but that sets the stage for other other treatment options to be used and our idea is to use them in an on andof fashion 3 weeks on on 3 weeks off uh the
• 05:00 - 05:30 stand I am a proponent of standard of care chemo radiation and immune therapy I think for many cancers uh these can be highly effective and well tolerated I've communicated with enough patients that they get a much better response if they're on the ketogenic diet and uh and the side effects are much less too if they're on the ketogenic diet hyperbaric oxygen therapy we're just in animal model studies now but it's like the studies that I showed you what I was doing 10 years ago when I was looking at brain tumors and the cells in the
• 05:30 - 06:00 mitochondria were exploding and the normal healthy brain cells were not I mean that was sort of very convincing to me that High Press oxygen was far more toxic to cancer cells than they were to normal healthy cells and we published that observation in Neuroscience but really didn't package it as an anti-cancer effect it was just like an interesting observation uh IV vitamin C and David Diamond turned me on to this uh that vitamin C is a glucose anti Agonist vitamin C at high levels in
• 06:00 - 06:30 Millar concentration can be a prooxidant and can actually drive Redux chemistry uh it can drive the hab Weiss reaction and Fenton chemistry and it Redux biochemistry in a way that actually stimulates uh reactive oxygen species production and oxidative stress so it could be used as a prooxidant therapy with or without hyperbaric oxygen therapy but I think it would work better with hyperic oxygen therapy and a whole
• 06:30 - 07:00 uh toolbox of metabolic drugs so we're doing these studies now uh in pre-clinical animal models and we're looking at breast cancer brain tumors and lung cancer we're looking at a variety of different things the mice live a lot longer they look healthier so we said we got to put this together in a in a something that humans can use so we developed the Press pulse therapeutic strategy and this is the outline for that and uh
• 07:00 - 07:30 George Yu um is an oncologist uh Joe maroon is the team surgeon for the Pittsburgh Steelers and neurosurgeon and Dominic di austino another colleague of mine from University of South Florida we put this paper together and this is an outline of press pulse the diet is a press we stress the tumor cells so they can't grow very fast so we have ketogenic diets and Ketone supplementation maybe MCT oils or some ketones we keep the pressure on the cells the patient comes comes in he's sick he's got metastatic
• 07:30 - 08:00 cancer brain cancer colon cancer they're all the same all cancers are exactly the same when it comes to their metabolism so whatever cancer they have we put them on the metabolic therapy they're all stressed out cancer creates stress when you have cancer you have anxiety you have impending that you're doomed maybe this I have something that especially when it starts to spread you get all freaked out so what we do is we use Stress Management we have exercise we have yoga therapy massage therapy music therapy all kinds of therapies
• 08:00 - 08:30 that reduce the patient's stress because when the patient is stressed cortisol is up glucose is up not good you got to bring the glucose down get rid of the stress put them on these metabolic therapies and then we pulse with drugs that further Target glucose like insulin and 2 deoxy glucose and then we use glutamine Inhibitors like like glutathione correction chloroquin and and egcg I'll talk about that and then we put him in hyperbaric oxygen Chambers instead of radiation we put him in Hyperbaric hyperbaric oxygen will kill
• 08:30 - 09:00 tumor cells as long as you can get rid of the glucose and glutamine why you radiate somebody when you can do this right so the patient then starts to feel better now a lot of these people who come in they're all screwed up anyway they got diabetes they got all kinds of metabolic imbalances all that seems to go away along with their cancer so uh then they start feeling better they get fewer and then we get resolution I don't know if we cure the disease I don't want to say we cure people I don't know if we cure people all I know is they're hell of a lot healthier than they were when they started how long they live I don't know
• 09:00 - 09:30 because we just started this stuff how how many how many long-term survivors you know there all I know is the ones that many of the ones we treat are living what what am I supposed to say and some die okay because it requires compliance and sometimes these people are not compliant and that's another I can't do anything about that so here's our most recent paper that we just published a couple of months ago um out of Egypt because we can't do this stuff in the United States you know we can't do it in England uh we can't do this so
• 09:30 - 10:00 this elsaka came to me and he says I'm using your metabolic therapy to treat gleo blastoma patients I said wow so these guys they it's hard to write I do that for a living I've written you know dozens and hundreds of scientific papers for journals so and I I know how to organize data I know how to write the data and I know how to present the information the clinicians get the data we can we can formulate it put it in the right order and then we can publish it so this is a guy 38-year Old Gentleman he was a farmer corn farmer in Egypt uh
• 10:00 - 10:30 he came in with his whole left side dragging he couldn't move his arm he was he was in bad shape he was also out of balance in vitamin D he was Tri had elevated triglycerides he he was metabolically a mess all right so we put him on the key I'll show you what we did um if I have it on the next slide well we took him water only therapeutic fasting water only therapeutic fasting for three days then he went into a 900 kilo calorie a day for three weeks no we
• 10:30 - 11:00 didn't do any bul debulking then after 3 weeks of this they took an awake crad onomy and we took the tumor out of this guy and as soon as we took the tumor out we brought him back on the metabolic therapy and we used chloroquin egcg hypobaric oxygen after three months he went in for the radiation and I said why are you putting them in the rad well we have to do that because everybody has to do that you're going to lose your license if you do that don't do that so I said anyway we put him on there he he said that he was prepared now his body was prepared so um so look at we brought
• 11:00 - 11:30 his glucose Ketone index down really good during this whole these treatments now here's this tumor in the brain by MRI analysis you see that white spot that's his tumor that was preoperative before there was any surgery taken so you can see and you can see the red line here this red line is shifted massively that's what I said the tumor grows in the brain and causes midline shift the and that's why he's paralyzed he's he's getting this part of his brain crushed so as we began the metabolic therapy I took and we did all this metabolic you
• 11:30 - 12:00 can see the the shift coming out it's a combination between the debulking and the metabolic therapy and all the other treatments so the guy after 24 months uh and he's still going he went back working in the in the cornfield uh he was doing really well no steroids we gave the guy no steroids so it goes to show you that we can achieve a far better oh that's only one patient listen it's not we got to write more and more of these patients it just takes time and my and then we did it in Turkey for
• 12:00 - 12:30 breast cancer and this was uh we have a big clinic in Turkey now that are doing this and this is a woman who came in she was also about 30 30 something I can't remember uh triple negative breast cancer which is not good and it spread to her liver and and part of her muscles and and what happens is that we now have management look at this she's doing really well okay so what we have we have the choice here's Britney standard of care Pablo ketogenic metabolic therapy so how many how many more Pablos can we
• 12:30 - 13:00 get cancer is a type of mitochondrial metabolic disease it's not a genetic disease this is the singular greatest misunderstanding and it's the singular greatest tragedy in the history of medicine this misunderstanding about what cancer is it's a it's a metabolic disease it lives on fermentation fuels if you restrict the two fuels you can manage any kind of a cancer because they all depend on either glucose glutamine or both and the Press pulse metabolic
• 13:00 - 13:30 therapy is non-toxic coste effective and in my mind it'll eventually make all other cancer therapies obsolete all right it's just a matter of time because people want to live and don't want to be poisoned and irradiated