ClaudePrism is a local-first scientific writing workspace that keeps your files on your disk, compiles offline, and edits locally. Unlike cloud-based alternatives, your documents never leave your machine for storage. AI features send content to Anthropic's API for inference, the same as any Claude-based tool.
The editor combines CodeMirror 6 with LaTeX/BibTeX syntax highlighting, real-time error linting, and multi-file project support. Tectonic is embedded directly in the app for offline LaTeX compilation with no TeX Live installation required. Packages download once and cache locally.
The built-in Python environment integrates uv for one-click setup. Claude Code automatically uses the project virtual environment when running Python code, so you can generate plots, run analysis scripts, and process data without leaving the editor.
ClaudePrism ships with 100+ scientific skills from K-Dense Scientific Skills across bioinformatics (Scanpy, BioPython, PyDESeq2), cheminformatics (RDKit, DeepChem, DiffDock), ML (PyTorch Lightning, Transformers, SHAP), clinical research (ClinicalTrials.gov, ClinVar, DrugBank), and more. Skills install globally or per-project and Claude loads them automatically.
The Claude AI assistant integrates directly in the editor with model selection (Sonnet, Opus, Haiku), adjustable reasoning effort, persistent sessions, tool use, and slash commands. When Claude suggests edits, changes appear in a dedicated panel with visual diffs where you accept or reject per chunk.
Every save creates a snapshot in a local Git repository. Label important checkpoints, browse diffs between snapshots, and restore previous versions. The Capture and Ask feature (Cmd+X) lets you drag-select any region in the PDF preview and immediately ask Claude about equations, figures, or reviewer comments.
The project has 1.3k GitHub stars, 307 commits, and is open source under the MIT license. It supports macOS, Windows, and Linux as a native Tauri 2 desktop application.